Isang napakalaking tagumpay sa paghahanap ng lunas para sa d1abetes ang nagawa ng mga researchers na naging matagumpay sa pagamot ng d1abetes sa isang daga sa unang pagkakataon gamit ang converted human cells.
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Ang human stem cell strategy functionally ginamot ang sakit sa daga sa loob ng di bababa sa 9 na buwan at sa ibang kaso ay umaabot pa ng isang taon, na nagbibigay naman pag-asa sa milyong katao na may sakit nito sa buong mundo.
Ang converted cell ay na a-allow sa isang daga na maka produce ng mabilis at tamang insulin para e breakdown ang high blood sugar na syang pinagsimulan ng d1abetes. Resulta ng mga tests ay nagpapakita na ang kanilang sugar levels ay bumalik sa normal at safe level sa loob ng dalawang linggo.
Nasa 400 milyon katao sa buong mundo ang may d1abetes, na sa ngayon ay walang tiyak na gamot. Mina-manage ng tao ang ganitong uri ng sakit sa pamamagitan ng pag diet, lifestyle changes at medication.
Dagdag pa sa ulat ng Daily Mail:
Scientists at the Washington University School of Medicine in St. Louis revealed on February 24 that they had successfully converted human stem cells into insulin-producing cells and demonstrated in mice infused with the converted cells that they can act as a rapid cure to d1abetes.
The research transformed other types of cells into beta pancreatic cells which produce the insulin hormone needed by the body to break up blood sugar.
The findings were published in the journal Nature Biotechnology.
‘These mice had very severe d1abetes with blood sugar readings of more than 500 milligrams per deciliter of blood — levels that could be fatal for a person — and when we gave the mice the insulin-secreting cells, within two weeks their blood glucose levels had returned to normal and stayed that way for many months,’ said principal investigator Dr Jeffrey R. Millman, an assistant professor of medicine and of biomedical engineering at Washington University.
The researchers initially discovered how to convert the cells several years ago but with certain flaws. After conversion, about a quarter of the cells were not insulin-producing but other kinds of beta cells such as liver cells.
While not harmful to the mice, these cells went no way to combat the high blood sugar problem or diabetes, making the overall process ineffective.
‘A common problem when you’re trying to transform a human stem cell into an insulin-producing beta cell — or a neuron or a heart cell —is that you also produce other cells that you don’t want,’ Millman explained in a statement from the university.
‘In the case of beta cells, we might get other types of pancreas cells or liver cells.
‘The more off-target cells you get, the less therapeutically relevant cells you have,’ he added.
‘You need about a billion beta cells to cure a person of d1abetes. But if a quarter of the cells you make are actually liver cells or other pancreas cells, instead of needing a billion cells, you’ll need 1.25 billion cells. It makes curing the d1sease 25% more difficult.’
After their initial findings, the research team returned to the cells’ conversion, looking to the internal scaffolding, known as the cytoskeleton, which forms a cell’s shape and allows it to interact with its surrounding environment.
This is turn allows the cell to convert a physical interaction into a biochemical symbol, such as the production of insulin when a beta pancreatic cell encounters blood sugar.
The prospective cure remains a long way off from being used on humans as extensive tests must still be carried out to confirm its safety and accuracy.
The next step in the research will include testing the cells on larger animals and for longer periods of time.
The process would also need to be automated if there was any hope of the treatment acting as an alternative to the insulin injections many d1abetic patients currently rely on.
The research still remains encouraging as the first time a mouse, a mammal, has been functionally cured of the d1sease which has previously been thought to be incurable.